The use of antacids containing acid or alkaline compounds has been reported to cause gastro-intestinal disturbances, especially in people with heart disease or heart failure [
,
]. These antacids may cause excessive bloating and water retention and/or diarrhea. These changes in acid or alkaline substances may lead to gastrointestinal symptoms like constipation, dry mouth, and stomach pain [
Gastrointestinal disturbances are one of the leading causes of death worldwide [
In the present study, we used the combination of two drugs, esomeprazole (Nexium) and omeprazole (Prilosec) to investigate the association between gastrointestinal symptoms induced by these antacids and the occurrence of gastro-intestinal disturbances in patients with a history of heart failure, heart failure, or angina (heart valve disease).
We found a significant association between the occurrence of gastro-intestinal disturbances and the use of antacids containing acid or alkaline compounds. Gastrointestinal disturbances, especially constipation, were observed in 8 of the 24 patients (50%) who used an antacid containing acid or alkaline substances and in the remaining 3 patients (17%) who used an antacid containing alkaline substances. This finding is consistent with previous studies, which demonstrated that antacids containing acid or alkaline substances are associated with a higher risk of developing gastrointestinal complications [
The mechanism of action of antacids containing acid or alkaline substances is related to their ability to decrease gastric acidity, which may lead to excessive gastric acidity in patients with heart failure, heart valve disease, or angina. Gastrointestinal disturbances are characterized by a decrease in gastric acidity and a loss of stomach-protecting capacity. Gastrointestinal disturbances are often due to the accumulation of ingested stomach contents in the gastrointestinal tract and/or reduced gastric acidity. These disturbances may result in excessive gastric acidity in patients with heart failure, heart valve disease, or angina. Antacids containing acid or alkaline substances are not effective for the treatment of heart failure, heart valve disease, or angina, and may have a negative impact on gastrointestinal complications [
As a result, there is an increased demand for the prevention and treatment of gastro-intestinal disturbances. We also studied whether the use of an antacid containing acid or alkaline substances was associated with the development of gastro-intestinal disturbances in patients with a history of heart failure, heart valve disease, or angina.
The main objective of this study was to investigate the association between the occurrence of gastro-intestinal disturbances and the occurrence of gastric and duodenal ulcers caused by these antacids. We also investigated the potential protective effects of these antacids against the development of gastric and duodenal ulcers.
The present study was a retrospective, cross-sectional study. The institutional review board of Shanghai University of Science and Technology, China, approved this study and no data were collected during the research. The patients with a history of heart failure, heart valve disease, or angina were included in the study. They were identified by the Shanghai Heart Failure Study Group (HFS-G) and followed for at least 7 days after hospital admission. The patients were divided into two groups: those with a history of heart failure and those without a history of heart failure or angina. All patients were admitted to the hospital with angina or heart failure. A history of heart failure, heart valve disease, or angina was confirmed before admission. Patients with an angina were admitted to the hospital with heart failure or angina.
The patients were diagnosed with chronic heart failure using the International Index of Eukaryotic Hypertension, the World Health Organization (WHO) criteria for heart failure, or the American Heart Association (AHA) criteria for heart valve disease [
This study was approved by the Ethics Committee of Shanghai University of Science and Technology (Approval No. 2022-01-08).
The patients were informed about the study and the study protocols. They gave their written informed consent to participate in the study.
The study protocol and procedure were explained to the patients and their doctors.
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Lasting relief for frequent heartburn and acid reflux.
Always read the label and follow the directions for use.
Nexium 24HR 20 mg enteric coated tablets for the lasting symptomatic relief of frequent heartburn, acid regurgitation and other symptoms associated with gastro-oesophageal reflux.
Always take this medicine exactly as described in the Consumer Medicine Information leaflet or as your doctor or pharmacist have told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is one tablet a day. - Do not take more than this recommended dose of one tablet (20 mg) a day, even if you don't feel an improvement immediately. - You may need to take Nexium 24HR for a few days before experiencing the full effect. - Nexium 24HR should be taken for at least 7 days and up to 14 days. - Tell your pharmacist or doctor if you do not feel better while taking Nexium 24HR. If symptoms persist or recur within 2 weeks of completing the course, consult your doctor. Further examination may be required.
Always read the label, use only as directed. Tell your pharmacist or doctor if you notice any of the following and they worry you: nausea or vomiting, constipation, diarrhoea, headache, wind, stomach pain, skin rash, itchy skin, dizziness or dry mouth. These side effects are usually mild. Tell your pharmacist or doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines may interfere with Nexium 24HR. Do not take Nexium 24HR if you are pregnant unless your doctor says so. Ask your doctor about the risks and benefits involved. It is not known if it is safe for you to take Nexium 24HR while you are pregnant. It may affect your baby. Do not take Nexium 24HR if you are breastfeeding. Ask your doctor for more information. It is not known if Nexium 24HR is excreted in breastmilk if you are breastfeeding.
Xue ZuziforUnexpected changes in behavior or mood have been reported in up to 80% of children after treatment with esomeprazole. The use of Nexium 24HR may lead to changes in the following cases: nausea, vomiting, drowsiness, difficulty in breathing, agitation, restlessness, vomiting, pruritus, stomach pain, headache, vomiting with a bad taste, dry mouth, and increased appetite. If you experience these symptoms within a few days, seek medical attention. Tell your doctor if you are taking any other medicines, including those made by your own medicines list. Some medicines may interfere with the action of Nexium 24HR. Do not take Nexium 24HR if you are taking:
medicines used to treat HIV-1 or hepatitis C infection such as amsacrel, esomeprazole, lansoprazole, pantoprazole or rabeprazole (Roquin). If you are taking sucralfate or bicarbonate plications, including heart failure and pH-sensitive heart failure (Na+-Cloporiazepone), lopinavir or ritonavir, telaprevir or intoranzol depending on the indication, take Nexium 24HR only if the potential benefits are greater than the risks. Tell your doctor if you are taking any of the following medicines:
Amphetamine or astemizole (Astemizole) or astemizole (Astemizole). If allergic reaction, discontinue the medication and report to your doctor immediately. Amnion (Amaryl) may rarely increase the risk of developing esomeprazole-induced gastro-oesophageal reflux since Amaryl can cause this effect.
Proguanil (Guanad) may rarely increase the risk of developing liver-related side effects.
Gonadotropic hormone analogues such as prazosin (Minipress) or zidovudine (Zadrog), dexamethasone (Decir), ethambutol (Metadate) or prednisone.
Metformin or metformin (Glucotrol).
Alternate Name:Pharmapure RX Esomep-EZS
Description:Nexium treats gastroesophageal reflux disease (GERD), esophagitis, and stomach ulcers. The generic version of Nexium is esomeprazole magnesium. For a supply of 30 oral tablets of Nexium Delayed-Release Capsules 40 mg is approximately $287. Take advantage of our LowerMyRx discount to receive a typical Nexium discount of up to 80% off of the retail price at participating pharmacies near you.
Dosage Form:Capsule Delayed Release
Administration Route:By mouth
Drug Class:Gastric Acid Secretion Inhibitor, Gastrointestinal Agent
Generic Available:Yes
Strength:20 MG
Warnings:Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, vitamin B12 deficiency, or osteoporosis. This medicine may cause the following problems: Kidney problems, including acute tubulointerstitial nephritisIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)LupusFundic gland polyps (abnormal growth in the upper part of your stomach) This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Keep all medicine out of the reach of children. Never share your medicine with anyone. Stomach pain, nausea, vomiting, weight loss, bloody or black stools
Food Warnings:Do not use esomeprazole if you are also using medicines that contain rilpivirine., Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following: Atazanavir, cilostazol, diazepam, digoxin, erlotinib, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, rifampin, saquinavir, St John's wort, tacrolimus, voriconazoleBlood thinner (including clopidogrel or warfarin)Diuretic (water pill)Iron supplements, This medicine can cause diarrhea. Diarrhea can occur 2 months or more after you stop taking this medicine., Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results., Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments., Keep all medicine out of the reach of children.
Appc medicine StorageMedicine should be kept at room temperature, 15 - 30 minutes before or after applesauce, ice water, and other moisture. Do not keep any medicine in the bathroom or the freezer. Do not store chewing food, chewing alcohol, or medicines unless they have a name and description. It is important to let your doctor and your pharmacist know that you are using this medicine. If you have any questions about this medicine, contact your doctor or pharmacist. Notify your doctor if you are using this medicine or if you are pregnant, planning to become pregnant, or if you are breast-feeding. Ask your doctor about the risks to your doctor.Signs of healthAppointmentsRegisteringHealthcareOnlineNexium Delayed-Release Capsules 40 mg StorageMedicine should be kept at room temperature, 15 - 30 minutes before or after applesauce, ice water, and other moisture.The price of one of the most popular prescription drugs in the world is estimated to be between $1,500 and $2,000. AstraZeneca has announced that the manufacturer of Nexium, a generic version of the blockbuster medicine used to treat heartburn, is facing an average of $100 per person each year, with the average price per person ranging from $15 to $30.
The average price for the brand-name drug is around $6,000, and AstraZeneca has also announced that the company is seeking to set aside an undisclosed amount to settle a lawsuit filed by the plaintiffs in the case relating to the use of the drug to treat heartburn. The lawsuit was filed in the Federal District Court of the Northern District of California against Teva Pharmaceutical Industries, a division of AstraZeneca, Inc. The complaint alleged that AstraZeneca’s generic versions of Nexium and the brand-name versions of the drug were used by consumers and that the company had paid the price of about $2,000 in kickback money.
Nexium 24HR Tablets 20 mg, 40 mg and 80 mg (Allergy Relief)contains the active ingredient esomeprazole 20 mg. This drug has a very short half-life, which means that it is not affected by food or the animals being treated. It is recommended that patients follow a strict dosage schedule to preserve the efficacy of this medication.
The active ingredient in Nexium 24HR 20 mg, also known as Esomeprazole 20 mg, is a proton pump inhibitor (PPI) that reduces the amount of acid produced by the stomach by blocking the production of gastric and duodenal mucosal hormones (GestationalEstradiolandProgesterone). This drug is used in the treatment of conditions related to gastroesophageal reflux disease (GERD), such as peptic ulcers. It also can be used to treat acid reflux disease (GERD) in individuals who are at risk of developing it.
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